• DRB (HIV Transcription Inhibitor): Decoding RNA Polymeras...

  2025-09-26

  Explore how 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB), a potent transcriptional elongation and CDK inhibitor, is reshaping HIV and stem cell research. This article uniquely integrates RNA polymerase II inhibition with phase separation dynamics, offering advanced insights beyond existing DRB literature.

• DMXAA (Vadimezan): Redefining Endothelial Immunity and Tu...

  2025-09-25

  Explore how DMXAA (Vadimezan, AS-1404) advances cancer biology by targeting tumor vasculature and modulating endothelial immunity. This in-depth article uniquely analyzes DMXAA’s integration with STING-JAK1 signaling and its translational implications beyond conventional vascular disruption.

• Dlin-MC3-DMA: Transforming mRNA and siRNA Delivery via LNPs

  2025-09-24

  Discover how Dlin-MC3-DMA, a leading ionizable cationic liposome, revolutionizes lipid nanoparticle siRNA delivery and mRNA drug delivery lipid platforms. This article uniquely explores predictive formulation, translational applications, and future directions for gene therapy.

• Sulfo-NHS-SS-Biotin Kit: Enabling Reversible Cell Surface...

  2025-09-23

  Explore how the Sulfo-NHS-SS-Biotin Kit, a water-soluble amine-reactive biotinylation reagent, empowers advanced studies of reversible biotin labeling with disulfide cleavage for selective cell surface protein analysis and purification.

• The proposed formulation is however challenging to solve sin

  2025-03-03

  

  The proposed formulation is, however, challenging to solve since the structured sparsity-inducing norms are non-smooth. In order to solve the new objective function, we consider two different approaches: proximal averaging, which takes the average the solutions from the proximal operator for the ind

• We stimulated HNEpC cells with

  2025-03-03

  

  We stimulated HNEpC cells with LPS found that the secretion of inflammatory cytokines and the expression of AHR was increased significantly, and miR124 was reduced. It has been found that LPS as a foreign substance can bind to the TLR family of proteins to activate intracellular AHR signaling [[19],

• The AR signalling pathways play important roles in

  2025-03-03

  

  The AR signalling pathways play important roles in several physiopathological processes associated with ischaemia, inflammation, and tumourigenesis [35]. Moreover, A3AR is overexpressed in different tumour cmv virus and seems implicated in pro- or anti-apoptotic effects [36]. In particular, activati

• Phosphodiesterase inhibition increases the intracellular lev

  2025-03-03

  

  Phosphodiesterase inhibition increases the intracellular levels of cAMP to restore spontaneous contraction (Essayan, 2001, Qi and Kwan, 1996), acting downstream of adenylyl cyclase. Therefore, cardiac arrest induced by decreased intracellular cAMP levels could be reversed by phosphodiesterase inhibi

• The synthesis and secretion of adrenal androgens is apparent

  2025-03-03

  

  The synthesis and secretion of adrenal androgens is apparently unique to humans and nonhuman primates, and requires the expression of key mediators such as CYP17 [26]. Endocrine control of CYP17 expression in rhesus monkeys is comparable to that in humans [27]. An analysis of baboon cDNA for CYP17 s

• br Experimental section br Acknowledgements br Introduction

  2025-03-01

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming R-848 in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively correlated with

• We further evaluated the possibility whether letrozole media

  2025-03-01

  

  We further evaluated the possibility whether letrozole mediates its effect through diverting the pathway towards 5α-DHT and further to 3α-Diol. For this purpose, we measured the concentrations of 5α-DHT and 3α-Diol in mice hippocampus and found that letrozole elevated both 5α-DHT and 3α-Diol levels

• There is a delicate balance between ROS

  2025-03-01

  

  There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the N-terminal protein labeling include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (F

• We made a number of choices in the original design

  2025-03-01

  

  We made a number of choices in the original design of our experiments. First, we used only portions of the 5′ and 3′ regulatory elements from S. cerevisiae. The sequences of these regions were known [32] and our goal was to express the Pf-DHFR at low levels. In fact, our choice of only 600 bp of the

• Sorafenib was the first small RTK inhibitor drug to

  2025-03-01

  

  Sorafenib was the first small RTK inhibitor drug to be developed and was initially approved against renal cell carcinoma, then against hepatocellular carcinoma (HCC) and more recently for differentiated thyroid treatment [111]. Sunitinib soon followed, being approved for gastrointestinal stromal tum

• Recent studies have supported the

  2025-03-01

  

  Recent studies have supported the existence of an inward RAS regulatory mechanism in which AT1 receptors downregulate angiotensin-converting enzyme 2 (ACE2) and subsequently impair angiotensin-(1-7) generation and MAS functionality (Jessup et al., 2006, Gallagher et al., 2008, Xia et al., 2009, Pern

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