• br Discovery of GPR A The murine niacin

  2021-12-15

  

  Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t

• Ca independent release of L

  2021-12-15

  

  Ca2+-independent release of L-[14C]glutamate and [3Н]GABA that occurs via transporters working in the reverse mode also insignificantly increased in vitamin D3 deficiency despite decreased GAT-3 and EAAC-1 cyclin dependent kinase and neurotransmitter uptake efficacy Fig. 3, Fig. 6 A). However, the

• Acknowledgments br Introduction The gut derived hormone

  2021-12-15

  

  Acknowledgments Introduction The gut-derived hormone oxyntomodulin (OXM) is a naturally occurring dual agonist of both the glucagon receptor (GCGr) and glucagons-like peptide 1 receptor (GLP-1r). Structurally OXM is the 29 SCH-900776 of glucagon with a C-terminal octapeptide tail. Administration

• Although domain organization had been clearly

  2021-12-15

  

  Although domain organization had been clearly delineated by the 4.3-Å structure of T4-γ-secretase [], atomic modeling of the side chains had to wait for the 3.4-Å structure []. In total, 598 residues in the transmembrane region and 632 residues in the ECD were modeled for the four components of huma

• One may ask whether induced loss through chemical

  2021-12-14

  

  One may ask whether induced loss, through chemical or genetic perturbation for example, of an essential cellular factor represents regulated cell death or simple loss of the homeostasis needed for life. For example, deletion of the Mdm2 gene, or inhibition of the MDM2 protein, results in cell death

• Introduction Protein tyrosine phosphorylation plays key role

  2021-12-14

  

  Introduction Protein-tyrosine phosphorylation plays key roles in a variety of intracellular signaling pathways involved in cell proliferation, differentiation, gene expression, cell adhesion, and metabolic changes [1]. While receptor-type tyrosine kinases localize to the plasma membrane, most of no

• br Introduction Regulation of transcription is a critical ev

  2021-12-14

  

  Introduction Regulation of transcription is a critical event of the embryonic development and epigenetic mechanisms such as histone modifications and DNA methylation appear important in mediating temporal changes, and differences among cells/tissues, of temporary stabilized transcriptomes (Mas et

• Maillard reaction also known as non

  2021-12-14

  

  Maillard reaction, also known as non-enzymatic browning reaction, is a complex chemical reaction between carbonyl groups of reducing sugars and free amino groups of amino acids, peptides, proteins or some other nitrogen containing compounds. Maillard reaction plays an important role in food industry

• Any brain damage including that caused by

  2021-12-14

  

  Any calcium channel damage, including that caused by β-amyloid, triggers activation of microglia, the resident immune cells of the CNS. These cells cluster around amyloid plaques, in which they extend cytoplasmic processes (Combs, 2009). The significance of this response is controversial, but one po

• Recent evidence suggests that HCA can also

  2021-12-14

  

  Recent evidence suggests that HCA2 can also mediate antineuroinflammatory effects [63]. Studies in this field were initiated when monomethyl fumarate, the metabolite of DMF, was shown to be an agonist of HCA2[5]. DMF at the same time was shown to not only have beneficial effects in the treatment of

• Although it is currently unknown why the

  2021-12-14

  

  Although it is currently unknown why the longer splice variant found in the human has not been found in any other species, similar results have been reported for other receptors, including the Adenosine Kinase Inhibitor hydrate receptor splice variant ERbeta2 identified in human and primate, but no

• Typically upon chronic agonist exposure GPCRs undergo desens

  2021-12-14

  

  Typically, upon chronic agonist exposure GPCRs undergo desensitization and internalization resulting in a loss of receptor responsiveness over time (Drake et al., 2006, Kelly et al., 2008). However, not all GPCR systems conform to this model of acute agonist-mediated regulation. Some receptors have

• While NR upregulation in the

  2021-12-14

  

  While NR1 upregulation in the spinal cord is known to contribute to pathological pain [7], [22] and furthermore, NR1 expression in the spinal cord has been shown to be reduced by continuous administration of the GlyT1-inhibitor ALX5407 [23], little is known about possible expressional changes of NR1

• To maintain low Glu concentrations in the

  2021-12-14

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino mgmt inhibitor is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, a

• Type diabetes mellitus is characterised

  2021-12-14

  

  Type 2 diabetes mellitus is characterised by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic beta bet inhibitor [1]. The condition occurs when the pancreatic beta cells are unable to compensate for increased insulin demand due to insulin resistance in

16158 records 552/1078 page Previous Next First page 上5页 551552553554555 下5页 Last page