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br Materials and methods br
2021-12-04
Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is
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br Materials and methods br Results br Discussion Accurate
2021-12-04
Materials and methods Results Discussion Accurate HER2 assessment for patients with invasive breast cancer is crucial to determining which patients may benefit from HER2-targeted therapy. The most recent ASCO/CAP guidelines have again redefined HER2 gene amplification as determined by dual-
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FRAX486 In fact most PIs are
2021-12-04
In fact, most PIs are susceptible to substitutions at Asp168, which are often present in patients who fail therapy (Pawlotsky, 2016). Notably, the polymorphism Gln168 at this position underlies reduced efficacy of PIs against GT3 (Soumana et al., 2016a). Glecaprevir and voxilaprevir have improved re
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Main Text There are over small GTPases
2021-12-04
Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, Fucoidan dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-bound “O
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In this study we demonstrated that while Cu I
2021-12-04
In this study, we demonstrated that while Cu(I) does not affect LPS induced iNOS Bisindolylmaleimide VIII acetate it inhibits NO release from microglia. Cu(I)-induced GSNOR inhibition and GSNO depletion is more in line with alternative (non-inflammatory) polarization. These results extend our previo
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br GPR a G protein coupled receptor GPCR was
2021-12-04
GPR35, a G protein-coupled receptor (GPCR), was discovered and classified as an orphan GPCR in 1998 and deorphanized in 2006 by the discovery of kynurenic 5,8,11-Eicosatriynoic Acid as the endogenous agonist. Since its discovery, limited references on the GPR35 receptor have appeared, due in part
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T lymphocytes play an important role
2021-12-04
T lymphocytes play an important role in cellular and humoral immunity and immune responses (Shin and Iwasaki, 2013; Schenkel and Masopust, 2014). T FDA-approved Drug Library receptor mature after complex selection and differentiation in the thymus. They can express various membrane proteins, such a
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br Results br Discussion secretase mediated proteolysis of
2021-12-03
Results Discussion γ-secretase-mediated proteolysis of integral membrane proteins is required for diverse biological processes (Lal and Caplan, 2011). One γ-secretase target of particular interest is Notch, as recent work has shown Notch activity to be increased in obesity and associated metab
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As shown in Table the
2021-12-03
As shown in Table 3, the results of individual prediction modeling with chemicals at 0.4 mM, 0.6 mM, and 0.8 mM would lead to lesser sensitivity of 60.0%, 65.0%, and 65.0%, respectively, in microsome-unused group, and 85.0%, 85.0%, and 90.0%, in microsome-used group. If we consider only the results
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br Characterization of quantal exocytosis by amperometry A s
2021-12-03
Characterization of quantal exocytosis by amperometry A secretory vesicle experiences four phases during exocytosis: (i) cargo packaging & translocation, (ii) vesicle docking & priming; (iii) fusion pore formation; (iv) fusion pore expansion and cargo secretion (Fig. 1a). The release of monoamine
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DIS used standard methods for locating and
2021-12-03
DIS used standard methods for locating and contacting persons for interview, including the use of phone calls, letters, in person contact, and contact through social media. During this time period, contacts of persons with diagnosed HIV (first-generation contacts) were tested for HIV and, regardless
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Studies have demonstrated the paradoxical role of
2021-12-03
Studies have demonstrated the paradoxical role of HO-1 in tumorigenesis. At initial stages of carcinogenesis, it protects DNA by lowering the ROS-mediated mutational rate, but later, HO-1 promotes cancer cell survival and proliferation. One PDAC therapeutic strategy is to increase ROS production and
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br Mechanism of HH pathway activation in
2021-12-03
Mechanism of HH pathway activation in NSCLC Despite the role of the HH pathway in basal cell carcinoma and medulloblastoma, it has been postulated that epithelial tumors do not demonstrate cell autonomous HH ligand activity. The main evidence comes from the study by Yauch et al showing no correla
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Vicenti et al assessed the prevalence of HCV
2021-12-03
Vicenti et al. [38] assessed the prevalence of HCV NS3/4A PI resistance mutations in HCV genotype 1-infected PI-naïve individuals, including 66 subjects coinfected with HCV/HIV. They found that 19.3% of isolates have at least one mutation related to PI resistance, and the HCV PI resistance mutations
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br Chemistry The methylsulfanyl dihydro H thieno
2021-12-03
Chemistry The 8-methylsulfanyl-4,5-dihydro-1H-thieno[3,4-g]isothiadizaole scaffold was synthesized from commercially available 1,3-dioxolane-2,1′-cyclohexane-4-one 17 (Scheme 1). The isothiadizaole ring was formed with SOCl2 from N-carboxamide hydrazine imine 19, which was prepared from 17 and hy
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