• We report here a patient

  2021-12-09

  

  We report here a patient with a one-base frame-shift deletion in the PURA gene that presented an unusual phenotype including persistent hypoglycorrhachia. We propose a possible link between hypoglycorrhachia and PURA dysfunction postulating PURA as a GLUT1 regulator. We therefore hypothesize that mu

• LJH685 br The hippocampus and spatial memory Numerous lines

  2021-12-09

  

  The hippocampus and spatial memory Numerous lines of evidence have implicated the rodent hippocampus in spatial forms of learning and memory (O’Keefe and Nadel, 1978). For example, hippocampal lesions produce robust and reliable deficits on spatial memory tasks such as the Morris watermaze in bot

• In the small intestine digestion and absorption of

  2021-12-09

  

  In the small intestine, digestion and protoporphyrin ix of the nutrients are the next processes with an impact on the resulting plasma profile. Normally, neither carbohydrate digestion nor absorption are limiting factors, which is illustrated by the rapid and extensive absorption of glucose in cond

• br Conflict of interest statement br Introduction br

  2021-12-09

  

  Conflict of interest statement Introduction Gap junction assembly Induced disassembly of gap junctions The regulation of connexin and gap junction turnover are still not well understood. This is, in part, due to the fact that while the overall turnover of connexin molecules is fairly con

• On the contrary the benzhydrol series showed modest

  2021-12-09

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the tetraethylammonium tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to

• In order to understand the

  2021-12-09

  

  In order to understand the determinants of high affinity of with amide side chain, an X-ray crystal structure of human liver FBPase in complex with was determined (). The position of phosphonate group and tricyclic scaffold of is similar to those of with no side chain, which suggests the formation o

• In non Hodgkin lymphoma the catalytic SET domain of

  2021-12-09

  

  In non-Hodgkin lymphoma the catalytic SET domain of the histone methyltransferase EZH2 is subject to recurrent heterozygous missense mutations . These alterations have been observed in ∼20% of patients with diffuse large B cell lymphoma (DLBCL) and ∼10% of patients with follicular lymphoma (FL). Th

• Figure shows the network of the persons with diagnosed

  2021-12-09

  

  Figure 2 shows the network of the 47 persons with diagnosed HIV and their 192 contacts. Of the contacts, 149 (78%) were first-generation contacts and 43 (22%) were second-generation contacts. Color and shape combinations used for network nodes (i.e., persons) allow one to simultaneously discern past

• Oxidative stress results from the

  2021-12-08

  

  Oxidative stress results from the disequilibrium between levels of prooxidant molecules produced and the ability of a biological system to detoxify and neutralize the reactive molecules [14]. OS is a chronic, self-perpetuating state of damage to cells and increased inflammation resulting from the co

• Several groups studied CTD mouse models which

  2021-12-08

  

  Several groups studied CTD mouse models, which largely mimicked the symptoms (i.e. impaired cognition and autistic-like behaviour) of the human disease (Kurosawa et al., 2012; Baroncelli et al., 2016; Stockebrand, 2018). The CRT-1 knockout mice showed a drastic deterioration in the GABAergic system,

• In vitro studies have shown that some antidepressant drugs b

  2021-12-08

  

  In vitro studies have shown that some antidepressant drugs bind to NMDA receptors and inhibit the binding of NMDA receptor ligands [18]. Similarly, several research teams have reported that tricyclic antidepressants can modulate the release and/or uptake of glutamate [19]. In this study, we found th

• br Materials and methods br Results br

  2021-12-08

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast BMX-IN-1 by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within minutes and

• In conclusion we provided the

  2021-12-08

  

  In conclusion, we provided the first evidence of a modification and regulation of GCK by O-GlcNAc modification that until now was not explored. This discovery provides important clues in the prevention of hyperglycemia and development of novel therapeutic drugs to treat type 2 diabetes. Acknowled

• The bFGF induced upregulation of

  2021-12-08

  

  The bFGF-induced upregulation of both GR and MR levels observed in our study raises a question regarding whether the simultaneous augmentation of the two receptors has a physiological and/or medical significance. It has been suggested that MR stimulates intracellular signaling pathways to minimize s

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2021-12-08

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by KN-92 deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of postm

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