• Introduction Human pathogenic Leishmania protozoa comprise d

  2021-12-17

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• br Materials and methods br Results br

  2021-12-17

  

  Materials and methods Results Discussion In this study, we demonstrated, for the first time, that manipulation of AKR1D1 expression and activity is able to regulate glucocorticoid availability in liver and non-liver cell lines. AKR1D1 over-expression leads to increased glucocorticoid cleara

• Cy7 NHS ester Receptors for glucagon Gcgr GLP Glp

  2021-12-17

  

  Receptors for glucagon (Gcgr), GLP-1 (Glp1r), and GLP-2 (Glp2r) are G-protein coupled receptors (GPCRs) belonging to class B-1 (secretin receptor-like) family of GPCRs (Harmar, 2001, Fredriksson et al., 2003). The mammalian Gcgr, Glp1r, and Glp2r genes, together with the Cy7 NHS ester for the recep

• br Hedgehog HH signaling plays an

  2021-12-17

  

  Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells, tissue repair, and regeneration (, ). Three ligands, Indi

• In this study we describe the expression

  2021-12-17

  

  In this study, we describe the expression of galr2a and galr2b in zebrafish embryos using whole-mount in situ RNA hybridization. To further analyze the distribution of GALR2b and its interactions with galanin, we generated Tg(galr2b:egfp) zebrafish, which express EGFP under the control of a galr2b p

• br Results br Discussion CD T cells are important

  2021-12-16

  

  Results Discussion CD8 T Miglitol are important for immune control of many viral infections (Ehtisham et al., 1993, Kagi et al., 1994, Mullbacher et al., 1999, Walsh et al., 1994). CD8 T cells are essential for efficient clearance of MAV-1 from the lungs and for airway inflammation during acu

• br Conclusion We have demonstrated that ETB receptors negati

  2021-12-16

  

  Conclusion We have demonstrated that ETB receptors negatively regulate the expression of AT1 receptors in renal proximal tubule AMG 487 synthesis from WKY rats but not in SHRs. Short-term activation of the ETB receptor increases AT1 receptor phosphorylation in WKY cells but decreases it in SHR c

• The lower number of samples

  2021-12-16

  

  The lower number of samples tested for the comparison between cobas 4800 HIV-1 and RealTime HIV-1, especially at or below 50 copies/mL (Table 6), could limit our ability to discern a difference in the ability of the various assays to identify patients with virological failure. However, the 95% CI ar

• Regulation of gene expression in mammalian cells is governed

  2021-12-16

  

  Regulation of gene expression in mammalian cells is governed by the epigenetic machinery, which includes several distinctive yet entangled branches. DNA and histone modifying enzymes, non-coding regulatory RNAs, and ATPase-dependent chromatin remodeling proteins all contribute to the dynamic alterat

• To identify genes with significant expression differences we

  2021-12-16

  

  To identify genes with significant LDN-212854 mg differences, we performed differential gene expression analysis between the two individuals with TRRAP variants (combined as biological replicates) and two unaffected controls. Gene ontology (GO) enrichment analysis of these genes with the GOrilla web

• Furthermore the identification of the inhibitory effect of P

  2021-12-16

  

  Furthermore, the identification of the inhibitory effect of P. grandiflorum and ginseng extract on HDAC represents an effective workflow for gene expression similarity-based repositioning of nutraceuticals. Acknowledgments This research was supported by Basic Science Research Program through the

• GPR is a member of the G protein coupled

  2021-12-16

  

  GPR119 is a member of the G protein-coupled receptor family, and is highly expressed in pancreatic β-cells and intestinal endocrine cells. It has been proposed that GPR119 agonists modulate glucose homeostasis by indirectly stimulating glucose-dependent insulin release through enhancing pancreatic c

• guanylate cyclase So far GnRH receptors have

  2021-12-16

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa guanylate cyclase of pre-ovulatory follicles, but not of follicles from the primor

• Using expression of TcMYH fused to GFP

  2021-12-16

  

  Using expression of TcMYH fused to GFP, it was observed that MYH is present in the nucleus and in the mitochondrion of T. cruzi (Fig. 5). It is known that MYH protein from human, rat and mouse exhibits both mitochondrial and nuclear localization (Ichinoe et al., 2004, Lee et al., 2004, Nishioka et a

• Here we performed TEM and AFM

  2021-12-16

  

  Here, we performed TEM and AFM imaging to study APE1–DNA interactions. The results showed that APE1 can dynamically polymerize on DNA in an apparently sequence-independent manner. We propose that this protein polymerization allows for scanning of the structural properties of DNA with short residence

15848 records 530/1057 page Previous Next First page 上5页 526527528529530 下5页 Last page