Archives
- 2018-07
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-07
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
- 2024-10
- 2024-11
- 2024-12
- 2025-01
-
In our reporter assay system C
2022-07-16
In our reporter assay system, C3H10T1/2-Gli1-Luc cells were incubated with Shh CM to induce Gli1-mediated luciferase activity (Fig. 1B). Z-Ajoene inhibited Shh CM-induced luciferase activity in a concentration-dependent manner as seen in Fig. 1C. Z-Ajoene also inhibited SAG (a Smo activator)-induced
-
Another consistent observation in our studies
2022-07-16
Another consistent observation in our studies was the lower plasma catecholamine concentrations in the exercised GHSR-null mice, suggesting a diminished sympathoadrenal response. A proper sympathoadrenal response is essential for increasing substrate utilization during exercise [81]. Thus, the reduc
-
Cartilage and subchondral bone synovial tissue interactions
2022-07-16
Cartilage and subchondral bone/synovial tissue interactions are well-recognized features of joint failure and osteoarthritis[17](seeFig. 1A, B). The intimate mechanical and biological interactions between these tissues are likely to alter the structural organization and function of either tissue. Ho
-
Gap junction intercellular communication GJIC facilitates th
2022-07-16
Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between [D-Lys3]-GHRP-6 through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1) depen
-
Recent evidence indicates that prolonged vasoconstriction of
2022-07-16
Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs APETx2 australia polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleation a
-
In addition to the regulation afforded
2022-07-15
In addition to the regulation afforded by calcineurin/NFAT axis, it has been shown that deregulation of some microRNAs (e.g. miR-155) can induce activation of Fas/FasL-in various cell types [72]. Furthermore, Fas–FasL interactions appear to be an important mechanism for the maintenance of immune pri
-
It should be noted that the
2022-07-15
It should be noted that the current studies were performed in female rats. Although the oestrous cycle has been shown to modulate inflammatory processes in the periphery, data from our group has demonstrated that the phase of the oestrus cycle does not significantly alter TLR3-mediated neuroinflamma
-
It is known that microglial function and morphology are clos
2022-07-15
It is known that microglial function and morphology are closely related [20], but no studies have addressed whether neuroinflammation induced by alcohol might modify microglial LXR-623 receptor (i.e. morphology, neuroimmunochemical phenotype) through an eCB-dependent mechanism. Since this alcohol-i
-
br Results br Discussion A key step in
2022-07-15
Results Discussion A key step in the regulation of gene WIN 64338 hydrochloride is the methylation on H3K4, which is added by the multi-component MLL/COMPASS-like histone methyltransferases. Many studies have shown the requirement of shared core subunits for optimal methylation activity of cat
-
sn38 australia Myelination by oligodendrocytes is required f
2022-07-15
Myelination by oligodendrocytes is required for saltatory nerve impulse conduction and proper CNS function (Bercury and Macklin, 2015). Defects in myelination and remyelination impair saltatory nerve conduction and functional connectivity leading to cognitive, behavioral, and motor deficits in neuro
-
More direct evidence of a role
2022-07-15
More direct evidence of a role for Hat1 in the acetylation of newly synthesized histone H4 has come from a number of recent studies that have shown that Hat1 is responsible for at least a portion of the acetylation that occurs on histone H4 lysines 5 and 12 in the pool of cytosolic histones. In chic
-
Introduction Histone is the core component of chromatin and
2022-07-15
Introduction Histone is the core component of chromatin and histone modification is one of the key mechanisms of epigenetic regulation (Bannister and Kouzarides, 2011). Amino 2-APB receptor residues on histone tails can be modified under different mechanisms including acetylation, methylation, pho
-
While more detailed molecular studies on
2022-07-15
While more-detailed molecular studies on the mechanistic basis for heightened H3 receptor function in PAE rats are underway, we have also been exploring whether PAE alters other markers of histaminergic neurotransmission in affected brain regions. One question is whether PAE affected the number of h
-
br Acknowledgments We thank Drs Yasuhiro Saito and Mitsuru F
2022-07-15
Acknowledgments We thank Drs. Yasuhiro Saito and Mitsuru Futakuchi for helpful discussion. We also thank Drs. Kohei Miyazono and Tadashi Matsuda for cells. This work was supported by Grant-in-Aids for Scientific Research on Innovative Area (16H06373; 16K15273) from MEXT, Japan (to M.H.) and by Pr
-
According to the literature HER mutations
2022-07-15
According to the literature, HER2 mutations are present in 2–4% of lung adenocarcinoma (ADC) patients. Most HER2 mutations are in-frame insertional mutations occurring at exon 20 in the protein kinase domain [[2], [3], [4], [5]]. Although several small molecules and HER2 Cinacalcet have been tested
15821 records 404/1055 page Previous Next First page 上5页 401402403404405 下5页 Last page