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In addition to peroxyl radicals the most
2022-11-14

In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as
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Because antioxidants have a strong radical scavenging effici
2022-11-14

Because antioxidants have a strong radical scavenging efficiency, a mixture of H2O2 and antioxidants should exhibit a much weaker depolymerization process than H2O2 alone. Therefore, we expected the redox behavior of silver could be affected by the presence of the antioxidant. The schematic diagram
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br Acknowledgements This work was supported in
2022-11-14

Acknowledgements This work was supported, in part, by NIH grant R01-GM071760. Introduction The MADS box genes encode a eukaryotic family of transcriptional regulators involved in diverse and important biological functions. This class of proteins has been identified in yeasts, plants, insects,
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Several strategies have been employed
2022-11-14

Several strategies have been employed to design and engineer peptide biosensors of kinase activity, which are quite different from the strategies developed to generate genetically encoded KARs. In all cases, crizotinib australia induces changes in the spectral properties of the fluorophore(s) incor
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br Findings br Discussion br Conclusions Midwives were
2022-11-14

Findings Discussion Conclusions Midwives were more likely to provide effective antimalaria services (including two doses of IPT during the second and third trimesters of pregnancy) to pregnant women if Conflict of interest Authors’ contributions Funding Acknowledgements Resea
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br Role of AR in models
2022-11-11

Role of AR in models of neointima formation Investigations into the pathogenesis of lesion formation have often used acute models of mechanical damage to assess the mechanisms regulating the fibro-proliferative response to arterial injury. Models of acute injury used for this purpose include: lig
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Adenosine receptors are proposed to
2022-11-09

Adenosine receptors are proposed to play proangiogenic role in vascular and immune Ergosterol mg within microenvironment of hypoxic tissues to maintain tissue oxygenation in chronic ischemic condition [9]. Adenosine also stimulates the production of angiopoetin-1, VEGF and Interleukin-6 (IL6) via a
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br Conflict of interest br
2022-11-09

Conflict of interest Acknowledgments This work was supported by research grant [PR26/20326] from Santander Bank/UCM. The authors would like to thank Miguel Capo, Professor of Toxicology from the Universidad Complutense de Madrid, for his counseling during the preparation of the present work.
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br Funding br Introduction l Dihydroxyphenylalanine l
2022-11-09

Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side
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Several tertiary prevention studies are
2022-11-09

Several tertiary prevention studies are currently underway examining the use of dutasteride for prostate cancer treatment: (1) during expectant management of prostate cancer, (2) after radical prostatectomy in men at high risk for relapse, and (3) in men with metastatic disease. The Reduction by Dut
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Introduction Apoptosis signal regulating kinase ASK a family
2022-11-09

Introduction Apoptosis signal-regulating kinase 1 (ASK1), a family member of the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family, selectively activates the JNK and p38 MAP kinase pathways in response to various types of stresses, including oxidative stress, and subsequently indu
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AMG 487 synthesis Although little is known about
2022-11-09

Although little is known about the etiopathogenesis of preeclampsia, this syndrome has a major impact on maternal and fetal health worldwide, since it is responsible for 10–15% of maternal deaths [16], [17], preterm births, intrauterine growth restriction (IUGR), and fetal deaths [2]. In developing
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Second the phosphorylation events e
2022-11-09

Second, the phosphorylation events (e.g., α-Thr172 and β-Ser108) needed for AMPK activation by small molecules binding at the ADaM or other sites remains unclear. Within the β-GBD, phosphorylation of β1-Ser108 was shown to be required for the activation by small molecules binding in the ADaM site, s
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br Acknowledgements br Introduction Diabetic complications a
2022-11-09

Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of BAMB-4 through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose reductase (AL
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br Conflict of interest statement br Introduction
2022-11-09

Conflict of interest statement Introduction Human saliva contains many detoxifying and antioxidant Mesoridazine Besylate like glutathione S-transferase, catalase, peroxidase, aldehyde dehydrogenase (ALDH), etc. [1]. Human salivary ALDH (hsALDH) protects individuals from toxic aldehydes contain
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