• On top of the hardware ASTS

  2019-07-11

  

  On top of the hardware, ASTS employs Linux SUSE with High-Availability (HA) Extension: a COTS OS provided with two clustering software (Pacemaker Cluster Resource Manager (CRM) and Corosync) responsible for resources orchestration, failure diagnosis, nodes coordination, and fail-over management. The

• The mammalian two hybrid results described above were

  2019-07-11

  

  The mammalian two-hybrid results described above were all obtained in 293T cells, and thus the higher RLU observed specific to the hCrm1 fusion could be consistent with human sphk having an unknown activator that interacts with hCrm1 HEAT repeat 9A and somehow facilitates Crm1-Rev/RRE function. Alt

• In summary we have identified a series of

  2019-07-11

  

  In summary, we have identified a series of amides as ERRγ agonists with suitable potency for further development. Our SAR studies of this chemotype identified SR19881 as the most potent full agonist of ERRγ with an EC=0.39 μM in a binding assay and an EC=4.7 μM in a cell-based assay. SR19881 was als

• In SLO permeabilized human sperm the AR elicited

  2019-07-11

  

  In SLO-permeabilized human sperm, the AR elicited by calcium, persistently active Arf6 [41] and Rab3A, 8-pCPT-2′-O-Me-cAMP [8], diacylglycerol and a non-hydrolyzable analog [35], is sensitive to the PLC blocker U73122. Furthermore, 8-pCPT-2′-O-Me-cAMP elicits a calcium signal in non-permeabilized sp

• Previous studies demonstrated that cPLA translocates to the

  2019-07-11

  

  Previous studies demonstrated that cPLA2α translocates to the phagosomal membrane during macrophage phagocytosis through mechanisms that, in humans, involve phosphorylation of the enzyme by c-Jun N-terminal kinases and membrane association via the cationic cluster of four lysine residues present at

• Methacholine MCh is a bronchoconstrictive agent that

  2019-07-11

  

  Methacholine (MCh) is a bronchoconstrictive agent that has been widely used in the diagnoses of airway narrowing and hyperresponsiveness (Jonasson et al., 2009). MCh induces muscle contractions by stimulating the muscarinic cholinergic receptors that are found in both the airways and the lung parenc

• Exposure to ultraviolet radiation with sunlight is generally

  2019-07-11

  

  Exposure to ultraviolet radiation with sunlight is generally accepted as the major cause of basal-cell carcinoma (Gallagher et al., 1995). The risk of this disease is significantly increased by age. Skin cancers are the most common tumours of the head and neck region and their prevalence shows progr

• Addressing whether impaired activation of D

  2019-07-11

  

  Addressing whether impaired activation of D1 and D2 receptors regulates memory capacity is relevant for all human pathologies that lead to reduced activation of these histamine-1 receptor antagonist pathways, such as ageing [39], certain genetic polymorphisms [40] and neurodegenerative disorders. In

• br Discussion The present results demonstrate that

  2019-07-11

  

  Discussion The present results demonstrate that high dose estrogen–progestogen OC treatment produced impaired glucose tolerance and glucose tolerance was preserved during low dose estrogen–progestogen, high or low dose progestogen-only OC use. The study also shows that impaired glucose tolerance

• A French cohort study reported that

  2019-07-11

  

  A French cohort study reported that micronized progesterone or didrogesterone used with oral or percutaneous estradiol showed no increase or decrease in the risk of breast cancer compared to synthetic progestins for at least 4 years of treatment [22] and even after 8 years [23]. Although the results

• Immature and mature B cells adapt differently to

  2019-07-11

  

  Immature and mature Biocytin adapt differently to signal transduction via BCR [2]. This functional dichotomy is also regulated by noncytokine substances in the surroundings of mature and immature B lymphocytes, such as the prostanoid family of lipid mediators including PGD2, PGE2, PGF2α, PGI2 and t

• Within the X CX PX RX motif of

  2019-07-11

  

  Within the X1CX3PX5RX7 motif of several prokaryotic FGE substrates, the residues of X3, X5, and X7 are variably found as mixtures of alanine, glycine, threonine, or serine residues [26], [27]. The docked model of our identified HCTPRRP motif revealed that position X1 (H1) and position X7 (P7) were n

• Future advances in the in vivo molecular imaging of enzyme

  2019-07-10

  

  Future advances in the in vivo molecular imaging of enzyme activity will greatly benefit from the progress towards the quantitative detection of enzymes. Quantitative imaging requires knowledge of both the location and concentration of a specific enzyme, which is dependent on the simultaneous measur

• We also identified Ubc as

  2019-07-10

  

  We also identified Ubc13 as a functional E2 for LNX1 and determined the complex structure of LNX1–Ubc13~Ub, which depicts the first step of the ubiquitination process (Fig. 3a.). Comparing structural alignment of the RNF4 RING: Ubc13~Ub: Ube2V2 complex (PDB code 5AIU) [33] and the RNF4:Ubc13~Ub comp

• br Results br Discussion Many studies have shown that intrin

  2019-07-10

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific Eltrombopag type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous st

16239 records 1043/1083 page Previous Next First page 上5页 10411042104310441045 下5页 Last page